THE SCIENCE
Retatrutide Halved Knee Pain for Two in Three Patients. Placebo Did It for 38%
By Grey Pepper Editorial
Knee osteoarthritis comes with a frustrating piece of standard advice: lose weight. The trouble is that painful knees make exercise difficult,...
THE SCIENCE
Ozempic’s Drug Changed How Stiff, Obese Hearts Fill With Blood. The MRI Study Scanned 49 People.
Doctors already knew that semaglutide, the active ingredient in Ozempic and Wegovy, could make people with obesity-related heart failure feel better. What they did...
THE SCIENCE
Explainer: Why GLP-1 Drugs Carry a Thyroid Cancer Warning, and Why a New Review Says It Should Go
Open the prescribing information for semaglutide and one of the first things you see is a boxed warning about thyroid tumors. Plenty of people...
THE SCIENCE
Brain Immune Cells May Shape How the Body Hears Leptin. An APOE4 Mouse Study Raises the Stakes
Most stories about appetite start with hormones. Leptin, made by fat tissue, tells the brain how much energy the body has stored; GLP-1 drugs...
THE SCIENCE
A GLP-1 Drug Nudged Down Prolactin in Healthy Young Men. Their Sex Drive Didn’t Budge
At a university hospital in Basel, Switzerland, two dozen healthy young men spent two four-week periods answering questions about their sex lives and receiving...
THE SCIENCE
Aging Muscle’s Repair Signal May Be Rusting, Not Running Out. A Sulfur Molecule Made It Grip Twice as Hard in the Lab
Here is an odd idea about aging muscle: the repair signal may not be running out. It may be getting chemically damaged before it...
THE SCIENCE
GLP-1 Drugs Beat Metformin at Preventing Diabetes in 256,000 Health Records. The Study Can’t Say Why
For years, the standard response to prediabetes has been relatively straightforward: improve diet, increase physical activity, lose excess weight and, for some high-risk patients,...
THE SCIENCE
Science Devoted a Special Section to GLP-1 Drugs. On Cancer, Memory and Addiction, Its Experts Say the Jury Is Out
When a journal like Science dedicates a special section to one class of drugs, it is a sign that a field has arrived. The...
